Step Into the
Future of Beauty

Evolysse is made with Cold-X Technology, the first major advancement in dermal filler technology in a decade.

The first two formulations, Evolysse Form and Evolysse Smooth, add volume to smooth smile and laugh lines for a year.**

** In most patients with optimal correction. Evolysse Form and Evolysse Smooth Directions for Use

Cold-X Technology

Temperature Matters

Cold-X Technology utilizes near-freezing temperatures intended to preserve the natural HA structure for a natural look

This novel approach with Cold-X Technology results in HA products that perform in the treatment area and are designed to feel natural in the facial tissue

Evolysse is the only treatment made
with Cold-X Technology

clinically proven

FDA Approved

Facial wrinkles may develop over time, often due to natural aging or after weight loss, with smile and laugh lines among common areas of concern. In fact, smile and laugh lines are the second most common area treated with dermal fillers.¹

The Evolysse collection of injectable hyaluronic acid treatments add volume to smooth smile and laugh lines.

A majority of people in Evolysse clinical studies were satisfied after treatment and reported²:

Smile and laugh lines look better when smiling and when relaxed*

They felt better about the appearance of their smile and laugh lines*

Results last 12 months**

They would recommend to a friend³

The most common side effects were temporary and at the injection site, such as tenderness, swelling, bruising, pain, redness, and lumps.

*In the clinical study, patients were asked to evaluate their results at specific time points. At six months after treatment with Evolysse, 64% were less bothered by how their nasolabial folds look when smiling; 65% were less bothered by how their nasolabial folds look when relaxed; and 65% were less bothered by how deep their nasolabial folds were.

** In most patients with optimal correction. Evolysse Form and Evolysse Smooth Directions for Use

Data on file. Dermal Filler Injector Survey, Evolus May 2024 (N=427)
Data on file. CLIN 2101 Clinical Study Report. Chaponost, France: Symatese SAS, 2024.
Evolysse Form and Evolysse Smooth Patient Labeling

Understanding

Hyaluronic Acid

Hyaluronic acid (HA) is a naturally occurring substance found in your skin that provides hydration to help skin maintain its flexibility and elasticity.

HA is also a key ingredient in many dermal fillers because it adds volume to the skin to smooth facial wrinkles.

Evolysse is made from a modified form of the HA that is naturally found in your body.

Available Soon

The first two formulations in the Evolysse collection 
– Evolysse Form and Evolysse Smooth – 
will be available in aesthetic practices soon. 

Get notified when Evolysse is available near you.

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Approved Uses

Evolysse™ Smooth and Evolysse™ Form are injected into the skin to smooth wrinkles that form in dynamic areas of the face, especially between the nose and corners of the mouth (NLFs), in adults 22 and older.

IMPORTANT SAFETY INFORMATION

Are there any reasons why I should not receive treatment with EVOLYSSE injectable hyaluronic acid products?

Do not use EVOLYSSE products if you have a history of multiple severe allergies or severe allergic reactions (anaphylaxis), or if you are allergic to lidocaine or Gram-positive bacterial proteins.

What precautions should my doctor advise me about?

Minimize exposure to extreme heat or cold as doing so may cause temporary redness, swelling, and/or itching at the injection site.
Tell your doctor if you are using medication that can prolong bleeding, such as aspirin, ibuprofen, or other blood thinners, as this may increase bruising or bleeding at the injection site.
Tell your doctor if you are planning laser treatment, chemical peel, or any other procedure after treatment as there is a possible risk of an inflammatory reaction at the treatment site.
EVOLYSSE products are intended for dynamic wrinkles and folds such as NLFs. The safety and effectiveness for other treatment areas have not been established.
Tell your doctor if you are on therapy used to decrease your immune response, which can increase risk of infection with treatment.
Tell your doctor if you are pregnant or breastfeeding. The safety for use during pregnancy or in women who are breastfeeding has not been studied.
Tell your doctor if you have a history of excessive scarring (thick, hard scars) or pigmentation disorders, as use of these products may result in additional scars or changes in pigmentation.
Tell your doctor if you have a history of cold sores. Any injections, including EVOLYSSE products, around the mouth may trigger a recurrence of your cold sores.
The use of EVOLYSSE products where skin sores, pimples, rashes, hives, cysts, or infections are present should be postponed until healing is complete. Use of EVOLYSSE products where these are present could delay healing or make your skin problems worse.

What are the possible side effects of treatment?

The most commonly reported side effects with EVOLYSSE products were tenderness, swelling, bruising, redness, lumps, pain, discoloration, itching, and headache. Most side effects were mild and went away on their own within 1 week.

What are other possible adverse events?

As with all skin injection procedures, there is a risk of infection.
One of the risks with using these products is unintentional injection into a blood vessel. Although the chances of this happening are very small, complications can be serious and may be permanent, and include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should call your doctor immediately.

To report a side effect with any EVOLYSSE product, please call the Evolus Customer Experience at 1-877-386-5871.

EVOLYSSE products are available only by a licensed physician or properly licensed practitioner.

US-EVY-2400002

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Approved Uses

IMPORTANT SAFETY INFORMATION

Are there any reasons why I should not receive treatment with EVOLYSSE injectable hyaluronic acid products?