Frequently Asked Questions

What exactly is Evolysse™?

Evolysse injectable hyaluronic acid gels add volume to smooth dynamic wrinkles and folds, such as smile and laugh lines.

How does Evolysse work?

Evolysse is injected into the skin with a fine needle to restore a smoother appearance to dynamic wrinkles and folds, such as smile and laugh lines.

WAS EVOLYSSE STUDIED IN DIFFERENT SKIN TYPES?

The Evolysse clinical study included patient representation from all Fitzpatrick skin types.

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When will I notice results with Evolysse?

Results with Evolysse are immediate and may last a year with optimal correction.

Is Evolysse safe? What are the side effects?

Evolysse is FDA-approved and only available by prescription, administered by a licensed aesthetic provider. The most common side effects observed in the clinical trial were temporary and at the injection site, such as tenderness, swelling, bruising, pain, redness and lumps. In clinical studies, there were no delayed onset nodules reported.

Is EVOLYSSE Reversible?

Yes. An enzyme called hyaluronidaise can be administered by your provider to dissolve Evolysse. One of the differences between injectable hyaluronic acid dermal fillers and other dermal fillers that are not made with hyaluronic acid is that fillers made with hyaluronic acid are reversible and can be dissolved.

How much does Evolysse cost?

There are several factors that determine how much Evolysse may cost. Meeting with an aesthetic provider near you to discuss your specific treatment goals is the best way to understand pricing.

Where can I find Evolysse?

Evolysse is now available at select practices near you. If you’d like to find an Evolysse provider near you to book a consultation, use our practice locator tool.

How is Evolysse different from other dermal fillers?

Evolysse is a collection of injectable hyaluronic acid treatments that add volume to smooth dynamic smile and laugh lines often caused by aging and weight loss. It’s the first to be developed with Cold-X Technology which is designed to protect the natural hyaluronic acid structure for a natural look and feel.

What is hyaluronic acid?

Hyaluronic acid (HA) is a naturally occurring substance found in skin that provides hydration to help maintain its flexibility and elasticity. HA has been a key ingredient in many dermal fillers for more than 20 years because it adds subtle volume.

What is Cold-X™ Technology?

Cold-X Technology utilizes near-freezing temperatures designed to preserve the natural HA structure for a natural look. This novel approach with Cold-X Technology results in hyaluronic acid products that perform in the treatment area and are designed to feel natural in the face.

Will I need the same amount as other fillers?

It depends. We recommend you consult with your health care provider who can help determine how much product you need for your desired outcome. In our clinical trials, Evolysse Smooth was studied against Restylane-L and delivered the same level of correction using 20% less product. In the clinical trial, the mean injection volume was 1.0 mL of Evolysse Smooth versus 1.2 mL of Restylane-L. The injection volume included the amount of product used at the first treatment plus an optional touch-up treatment at 2 weeks.

IMPORTANT SAFETY INFORMATION

Are there any reasons why I should not receive treatment with EVOLYSSE injectable hyaluronic acid products?

Do not use EVOLYSSE products if you have a history of multiple severe allergies or severe allergic reactions (anaphylaxis), or if you are allergic to lidocaine or Gram-positive bacterial proteins.

What precautions should my doctor advise me about?

Minimize exposure to extreme heat or cold as doing so may cause temporary redness, swelling, and/or itching at the injection site.

Tell your doctor if you are using medication that can prolong bleeding, such as aspirin, ibuprofen, or other blood thinners, as this may increase bruising or bleeding at the injection site.

Tell your doctor if you are planning laser treatment, chemical peel, or any other procedure after treatment as there is a possible risk of an inflammatory reaction at the treatment site.

EVOLYSSE products are intended for dynamic wrinkles and folds such as NLFs. The safety and effectiveness for other treatment areas have not been established.

Tell your doctor if you are on therapy used to decrease your immune response, which can increase risk of infection with treatment.

Tell your doctor if you are pregnant or breastfeeding. The safety for use during pregnancy or in women who are breastfeeding has not been studied.

Tell your doctor if you have a history of excessive scarring (thick, hard scars) or pigmentation disorders, as use of these products may result in additional scars or changes in pigmentation.

Tell your doctor if you have a history of cold sores. Any injections, including EVOLYSSE products, around the mouth may trigger a recurrence of your cold sores.

The use of EVOLYSSE products where skin sores, pimples, rashes, hives, cysts, or infections are present should be postponed until healing is complete. Use of EVOLYSSE products where these are present could delay healing or make your skin problems worse.

What are the possible side effects of treatment?

The most commonly reported side effects with EVOLYSSE products were tenderness, swelling, bruising, redness, lumps, pain, discoloration, itching, and headache. Most side effects were mild and went away on their own within 1 week.

What are other possible adverse events?

As with all skin injection procedures, there is a risk of infection.
One of the risks with using these products is unintentional injection into a blood vessel. Although the chances of this happening are very small, complications can be serious and may be permanent, and include vision abnormalities, blindness, stroke, temporary scabs, or permanent scarring of the skin. If you have changes in your vision, signs of a stroke (including sudden difficulty speaking, numbness or weakness in your face, arms, or legs, difficulty walking, face drooping, severe headache, dizziness, or confusion), white appearance of the skin, or unusual pain during or shortly after treatment, you should call your doctor immediately.

To report a side effect with any EVOLYSSE product, please call the Evolus Customer Experience at 1-877-386-5871.

EVOLYSSE products are available only by a licensed physician or properly licensed practitioner.

For complete patient label information, please visit EvolusRx.com

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